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- W2392769062 abstract "Objective To investigate the distribution and localization of divalent metal transporter 1(DMT1) in the cerebral cortex of APP/PS1 transgenic mouse, and to explore the possible role of DMT1 in Alzheimer disease (AD) pathogenesis. Method Immunohistochemistry, immunofluorescence and confocal laser scanning microscopy were used to analyze the distributions of DMT1 and β-amyloid protein (Aβ) and the relationship between these two proteins in cerebral cortex of APP/PS1 mouse. Results DMT1 immunoreactive product was seen to be localized in the senile plaques within the cerebral cortex of APP/PS1 transgenic mouse. Almost all of senile plaques presented DMT1 immunoreactivity with different expression. Confocal microscopic results revealed that a co-localization of DMT1 and Aβ was found in the senile plaques. Conclusion The abundant expression of DMT1 in Aβ senile plaques suggests that DMT1 may be involved in the deposition of Aβ and the formation senile plaque in AD brain." @default.
- W2392769062 created "2016-06-24" @default.
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- W2392769062 date "2008-01-01" @default.
- W2392769062 modified "2023-09-24" @default.
- W2392769062 title "Localization of DMT1 in Cerebral Cortex of APP/PS1 Transgenic Mouse Brain" @default.
- W2392769062 hasPublicationYear "2008" @default.
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