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- W2392769796 abstract "Objective:To study GnRH expression in cervical squamous cell carcinoma to explore its probable clinical significance.Method:GnRH in cervical squamous cell carcinoma and chronic cervicitis were detected by two respective methods of immunohistochemistry and in situ hybridization.Results:The expression of GnRH and GnRH mRNA in epithelium of 20 chronic cervicitis cases were negative but positive in 45 cervical squamous cell carcinoma cases.Positive rate was 80% for GnRH and 64.44% for GnRH mRNA.The expression of both protein and nucleic acid levels had statistically significant difference between chronic cervicitis and cervical squamous cell carcinoma.Qualitative and quantitative comparison for GnRH and GnRH mRNA were conducted between different clinical stages of cervical carcinoma tissues,the quantitative expression rate of GnRH were Stage Ⅰ 50%(6/12),StageⅡa 85.7%(18/21),StageⅡb-100%(12/12);and the quantitative expression rate of GnRH mRNA were StageⅠb 33.3%(4/12),StageⅡa 71.4%(15/21),StageⅡb-83.3%(10/12);qualitative comparison revealed significant differences(P0.05).The different expression of GnRH and GnRH mRNA in different clinical stage of cervical cancer showed qualitatively significant differences(P 0.05).Conclusions: GnRH and GnRH mRNA could be detected in cervical squamous cell carcinoma and might be involved in the development process.Our study provides a theoretical basis for a hypothesis that inhibition of GnRH secretion could help reducing the incidence and also a new treatment for cervical squamous cell cancer." @default.
- W2392769796 created "2016-06-24" @default.
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- W2392769796 date "2012-01-01" @default.
- W2392769796 modified "2023-09-25" @default.
- W2392769796 title "Expression of gonadotropin releasing hormone(GnRH) in cervical squamous cell carcinoma and its significance" @default.
- W2392769796 hasPublicationYear "2012" @default.
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