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- W2392776558 abstract "Objective To investigate the effects of interleukin-1 bet a(IL-1β),tumor necrosis factor-alpha(TNF-α) and interleukin-6(IL-6) induced by chronic alcohol administration on pancreatic islets in rats.Methods Rats were given alcohol solution(6?mg/kg·d) in different concentrations(10%,30% and 50%) through intragastric-feeding for 13 we eks.The serum glucose,insulin and the level of IL-1β,TNF-α and IL-6 were deter mined at the end of the study.Results Compared with the control group,serum glucose in 50% alcohol feeding,was increased and insulin was decreased( P0.05).The level of serum IL-1β,TNF-α and IL-6 were higher(P0.05 ).Chronic alcohol consumption also elevated the level of IL-1β,TNF-α and IL-6 in pancreas of female rats and the level of IL-1β and TNF-α in pancreas of mal e rats(P0.05).The content of IL-6 in pancreas had no differences in the f our groups of male rats(P0.05).Conclusion Chronic alcohol intake can impair insulin secr etion function of beta cells.Moreover,chronic alcohol intake can up-regulate the production of cytokines(IL-1β,TNF-α and IL-6).In a word,chornic alcohol intox ication may have effect on beta cells through cytokines." @default.
- W2392776558 created "2016-06-24" @default.
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- W2392776558 date "2004-01-01" @default.
- W2392776558 modified "2023-09-27" @default.
- W2392776558 title "IL-1β、TNF-α and IL-6 caused by chronic alcohol administration on pancreaticislets of rats" @default.
- W2392776558 hasPublicationYear "2004" @default.
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