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- W2392783229 abstract "Objective To observe the effect of L-carnitine (L-C) on the proliferation and apoptosis in human osteoblasts (hOB). Methods The effect of L-C on the proliferation of hOB cells was assessed by[ 3H ]thymidine incorporation. The effect of L-C on the apoptosis of hOB cells was analyzed by acridine orange/ethidium bromide staining and Cell Death Detection ELISA Kit. The protein active caspase-3,-9 was determined by Western blot analysis. Results Treatment with 10～100 mmol/L concentration of L-C to hOB cells promoted cell proliferation. 10～100 mmol/L L-C suppressed serum deprivation-induced hOB apoptosis. Western blot analysis confirmed that 10～100 mmol/L L-C reversed the serum deprivation-induced caspase-3,-9 activation in hOB cells. Conclusions L-C promoted the cell proliferation in human osteoblasts. L-C suppressed the cell apoptosis in human osteoblasts through the down-regulation of caspase-3,-9 activation." @default.
- W2392783229 created "2016-06-24" @default.
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- W2392783229 date "2007-01-01" @default.
- W2392783229 modified "2023-09-22" @default.
- W2392783229 title "Effects of L-carnitine on the proliferation and apoptosis in human osteoblasts" @default.
- W2392783229 hasPublicationYear "2007" @default.
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