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- W2392805394 abstract "Objective: To study cyclinD1/bcl-1 and p27/kip1 expression in gliomas and their correlation with pathological grade and prognosis. Methods: Immunohistochemical technique was used to detect the cyclinD1/bcl-1 and p27/kip1 expression in 48 human brain glioma tissues of different malignant grades, and 12 normal non-neoplastic tissues collected from internal decompression. The data were analyzed quantitatively by the image system and also correlated retrospectively with the patients' clinical characteristics. Results: The immunohistochemical reaction for cyclinD1/bcl-1 and p27/kip1 was confined to the nuclei. The abnormal positive expression rates of both cyclinD1/bcl-1 and p27/kip1 in gliomas were found higher than that in non-neoplastic tissues(P0.05). The number and staining intensity of cyclinD1/bcl-1 positive nuclei increased with malignant grades (P0.05). On the contrary, the positive nuclei of p27/kip1 expression decreased in number and staining intensity with malignant grades(P0.05). Higher expression of cyclinD1/bcl-1 or/and lower expression of p27/kip1 were associated with poor prognosis(P0.05). Conclusion: The abnormal expression of both cyclinD1/bcl-1 and p27/kip1 might be closely related to the occurrence and development of gliomas and they might have synergistic effect. These data suggest that both cyclinD1/bcl-1 expression and p27/kip1 expression can act as an independent prognostic factor." @default.
- W2392805394 created "2016-06-24" @default.
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- W2392805394 date "2004-01-01" @default.
- W2392805394 modified "2023-09-28" @default.
- W2392805394 title "Expression of CyclinD1/Bcl-1 and p27/Kip1 in Gliomas:Their Correlation with Pathological Grade and Prognosis" @default.
- W2392805394 hasPublicationYear "2004" @default.
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