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- W2392812675 abstract "Objective:To establish a GC method for determination and identification of related substances of amantadine hydrochloride. Methods:The related substances are analyzed with programmed temperature in a HP-5 capillary column by FID,and identified by means of mass spectrum obtained from impurities. Results:The area normalization method for determination of related substances of amantadine hydrochloride is validated,the limit of detection is 2 ng,the impurity A is amino-disubstituted adamantane,the impurity B is 2-aminoadamantane. Conclusion:The method is reliable and sensitive,and can be used for quality control of amantadine hydrochloride." @default.
- W2392812675 created "2016-06-24" @default.
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- W2392812675 date "2011-01-01" @default.
- W2392812675 modified "2023-09-23" @default.
- W2392812675 title "GC determination and identification of related substances of amantadine hydrochloride" @default.
- W2392812675 hasPublicationYear "2011" @default.
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