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- W2392820072 abstract "Porcine granulocyte-macrophage colony-stimulating factor (GM-CSF) is considered a potential molecular adjuvants for its ability to induce dentritic cell (DC) maturation and maintain its viabilities, and enhance antigen presentation function of DC. To investigate the regulatory effects of porcine GM-CSF on immune responses induced by porcine circovirus type 2 (PCV2) DNA vaccine, seven-day old healthy piglets were immunized in 2 groups, one was inoculated with a mixture of a porcine GM-CSF expressing vector (pcDNA3.1-mg-csf) and PCV2 capsid protein expressing vector (pcDNA3.1-orf2), and the other was inoculated with a bicistronic plasmid DNA encoding porcine GM-CSF and PCV2 capsid protein (pIRES-orf2/gm-csf). All piglets were injected three times by intramuscular at two-week intervals. The results showed that porcine GM-CSF gene could distinctly enhance specific humoral immune response to PCV2 DNA vaccine, the augment proliferation of peripheral blood lymphocytes (PBLC) stimulated with ConA and the lysis activity of NK cells. In addition, the GM-CSF was found to affect expression of IL-12?￠IFN-|??￠IL-4 and IL-10 in PBLC to various degrees, with different influences shown when GM-CSF gene was encoded in a single vector and in a bicistronic plasmid." @default.
- W2392820072 created "2016-06-24" @default.
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- W2392820072 date "2007-01-01" @default.
- W2392820072 modified "2023-10-03" @default.
- W2392820072 title "Modulation effects of porcine GM-CSF on immune responses in piglets induced by porcine circovirus type 2 DNA vaccine" @default.
- W2392820072 hasPublicationYear "2007" @default.
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