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- W2392828746 abstract "OBJECTIVE:To observe the effects of Tanreqing injection on the immune factors and clinical outcome in patients with ventilator associated pneumonia(VAP).METHODS:155 patients with VAP were randomly divided into trial group and control group.Serum levels of CRP,IL-6 and TNF-α were determined at 0,1,3,5 and 7 days after treatment.The chest X-ray results at 0 and 3 days after treatment were compared.The mechanical ventilation(MV)time and the successful rate of weaning from mechanical ventilation and the mortality rate were recorded.RESULTS:The serum levels of CRP,IL-6 and TNF-α in all 155 VAP patients were significantly higher than normal levels,at 5 days,serum levels of IL-6 and TNF-α in the trial group began to decrease significantly as compared with the control group(P0.05),on day 7,serum levels of CRP,IL-6 and TNF-α were significantly lower than in the control group(P0.05),and the MV time in the trial group was significantly shorter than in the control group(P0.05).The improvement rate of chest X-ray results at 3 days and the successful rate of weaning from mechanical ventilation in the trial group were all significantly higher than in the control group(P0.05),but the mortality rate of trial group was significantly lower than in control group(P0.05).Levels of CRP,IL-6 and TNF-α on day 7 were positively correlated with the MV time.CONCLUSION:As an adjunctive therapy for VAP,Tanreqing injection can attenuate the functional lesion of multi-organs secondary to VAP by suppressing excessive inflammatory reaction and facilitate partial recovery of immune function so as to shorten MV time,lower mortality and improve the clinical outcome of VAP." @default.
- W2392828746 created "2016-06-24" @default.
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- W2392828746 date "2009-01-01" @default.
- W2392828746 modified "2023-09-25" @default.
- W2392828746 title "Effects of Tanreqing Injection on Immune Factors and Clinical Outcome in Patients with Ventilator Associated Pneumonia" @default.
- W2392828746 hasPublicationYear "2009" @default.
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