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- W2392850965 abstract "Objective To study the protective effects of anthocyanin from Ipomoea batatas on thymocytes in Kunming mice damaged by ~(60)Co γ-ray(3 Gy). Methods The irradiation damage models of thymocytes were established by ~(60)Co γ-ray.The cells were randomly divided into six groups: control group,and 5 ~(60)Co groups(model,0.625 g/L,1.250 g/L,2.500 g/L,anthocyanin from Ipomoea batatas,and 1 g/L Vit C).The free calcium,mitochondria membrane potential and the rate of apoptosis of thymocytes were tested using flow cytometry(FCM).The expressions of P53 proteins were examined immunocytochemically.The p21 expression was determined with in situ hybridization.The scavenging properties of anthocyanin from Ipomoea batatas on superoxide anions(O~-_2),hydroxyl radical(OH~·),peroxynitrite(ONOO~-) and free radicals of lipids were determined with chemiluminescence and electron spin resonance(ESR) techniques. Results The concentration of cellular free calcium was decreased by Ipomoea batatas Poir.Ipomoea batatas Poir decreased the rate of apoptosis and the expression of P53.The mRNA expressions of p21 decreased in Ipomoea batatas Poir group.The anthocyanin from Ipomoea batatas could effectively scavenge O~-_2,OH~·,ONOO~-and free radicals of lipids. Conclusion Ipomoea batatas Poir has protective effects on damages of thymocytes caused by the ~(60)Co irradiation,whose mechanism might be related to the inhibition of free radicals,cellular free calcium and decreased expression of P53 and p21 gene,increased anti-oxidative enzymes in cells and inhibition of the lipid peroxide." @default.
- W2392850965 created "2016-06-24" @default.
- W2392850965 creator A5003705408 @default.
- W2392850965 date "2005-01-01" @default.
- W2392850965 modified "2023-09-26" @default.
- W2392850965 title "PROTECTIVE EFFECTS OF ANTHOCYANIN FROM IPOMOEA BATATAS ON THYMOCYTES IRRADIATION DAMAGE CAUSED BY ~(60)Co γ-RAY IN MICE" @default.
- W2392850965 hasPublicationYear "2005" @default.
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