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- W2392868032 abstract "This study is aimed to detect the effect of protease-activated receptor activation on IL-28 and IL-29 mRNA expression in A549 cells.Firstly,A549 cells were collected at 2 h,8 h and 16 h after stimulation with the optimal concentrations of thrombin,trypsin,tryptase and elastase and protease-activated receptors' activated peptide(PARs AP),then the cells were treated for detecting IL-28 and IL-29 mRNA expression by using quantitative real time polymerase chain reaction(PCR) technique.We found that thrombin upregulated IL-29 mRNA expression by up to 9.6-fold of control,but had little effect on regulation of IL-28 mRNA expression in A549 cells.In addi-tion,trypsin enhanced expressions of IL-29 and IL-28 mRNA by up to 6.1-and 4.4-fold of control,respectively,while tryptase increased expressions of IL-29 and IL-28 mRNA by up to 3.1-and 2.2-fold of control respectively in A549 cells.Elastase stimulated IL-29 mRNA expression by up to 5.1-fold of control,but had little influence on the expression of IL-28 mRNA in A549 cell.The PAR-1 AP,SFLLR,induced upregulated expression of IL-29 mRNA by up to 1.7-fold of control whereas PAR-1 AP exerted little effect on IL-28 mRNA ex-pression accordingly.Furthermore,PAR-2 AP(SLIGKV) or tc-LIGRLO induced up to 4.9-and 2.4-fold increase in IL-29 and IL-28 mRNA expression,while PAR-4 AP(GYPGQV) strengthened IL-29 and IL-28 mRNA expression by up to 4.1-and 5.5-fold of control,respectively.Whereas,PAR-3 AP(TFRGAP) had little effect on IL-29 and IL-28 mRNA expression.In conclusion,activation of PARs provoked up-regulation of IL-28 and IL-29 mRNA in A549 cells." @default.
- W2392868032 created "2016-06-24" @default.
- W2392868032 creator A5073510977 @default.
- W2392868032 date "2010-01-01" @default.
- W2392868032 modified "2023-09-27" @default.
- W2392868032 title "Effects of protease-activated receptor activation on IL-28 and IL-29 mRNA expression in A549 cells" @default.
- W2392868032 hasPublicationYear "2010" @default.
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