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- W2392876346 abstract "Objective: The observe clinical effects of treating cor pulmonale at acute phase(phlegm and blood stasis type indicates the lungs) through traditional Chinese medicine combined with western medicine and influence of hemorheology,endothelin-1(ET-1),thromboxane B2(TXB2) and 6-Ketone prostaglandin F_la(6-Keto-PG F_la) 's level. Method: Ninety patients were randomly divided into control group(45 cases) and observation group(45 cases). Patients in control group received conventional western medicine therapy,including controlling oxygen cure,anti-infection,expectorant,smooth wheezing,heart failure and other comprehensive measures. Based on the treatment of control group,patients in observation group added and subtract treatment of Xiaoxianxiong decoction,Sanzi Yangqin decoction and Xuefu Zhuyu decoction. Treatment courses continued for 4weeks. Measure arterial carbon dioxide partial pressure(PaCO2),oxygen partial pressure(PaO2),pulmonary artery pressure(mPAP) before and after treatment. Test hemorheology,ET-1,TXB2 and 6-Keto-PG F_ la's level before and after treatment. Record treatment of main symptoms and signs scores every week. Result: The total effective rate of curative efficacy in observation group was 91. 11% superior to 75. 56% in control group(P 0. 05). The level of mPAP and PaCO2 in observation group was lower than that in control group,while the level of PaCO2 in observation group was higher than that in control group after treatment(P 0. 01). Observation group's improvement of blood rheology indexes whole blood viscosity,plasma viscosity,fibrinogen,platelet aggregation rate and erythrocyte sedimentation rate were better than those data in control group(P 0. 01). The level of ET-1 and TXB2 in observation group were lower than the data in control group. At the same time,observation group's6-Keto-PG F_ la level was higher than that in control group after treatment(P 0. 01). At the first,second,third and fourth mouth after the treatment,main symptoms and signs scores in observation group were lower than those in control group(P 0. 01). Conclusion: Traditional Chinese medicine combined with western medicine can relieve symptoms and signs, ameliorate ventilatory function of lung, hypercoagulability of blood, high viscosity of blood and congestion of pulmonary circulation, reduce pulmonary artery pressure in treating cor pulmonale at acute phase,and it can improve clinical efficacy." @default.
- W2392876346 created "2016-06-24" @default.
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- W2392876346 date "2014-01-01" @default.
- W2392876346 modified "2023-09-28" @default.
- W2392876346 title "Chinese Combined Western Medicine Treat Cor Pulmonale During Acute Phase with 45 Cases" @default.
- W2392876346 hasPublicationYear "2014" @default.
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