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- W2392880003 abstract "Objective To explore the effect of erythropoietin(EPO) on apoptosis of human renal tubular(HK-2) cells induced by postasphyxial-serum of neonates.Methods HK-2 cells were used as target cells.The experiment was divided into 4 groups,control group(n=8):HK-2 cells were maintained in standard medium;asphyxia group(n=8):HK-2 cells were treated with serum obtained from neonates with asphyxia.Each culture medium replaced with 200 mL/L suffocation DMEM/F12 serum culture medium;EPO pretreatment group(n=8):HK-2 cells were pretreated 24 h with serum contains 5×104 IU/L EPO,and then deal as asphyxia group;EPO and 5-hydroxydecanoic acid sodium salt(5-HD) pretreatment group(n=8): HK-2 cells were pretreated 24 h with serum contains 5×104 IU/L EPO and 500 μmol/L 5-HD,and then deal as asphyxia group.All cells were cultured at 37 ℃ in humidified atmosphere with 50 mL/L CO2 for 24 h.The apoptosis rate of HK-2 cells was detected by flow cytometer.The expressions of Caspase-3 and X-linked inlnibitor of apoptosis protein(XIAP) of HK-2 cells were detected by using immunohistochemical method.Results Compared with control group,after stimulated with postasphyxial-serum,the apoptosis rate and the expression of Caspase-3 of HK-2 cells were significantly increased(Pa0.05),but compared with asphyxia group,both significantly reduced in EPO pretreatment group(Pa0.05),EPO-induced above protective effects could be inhibited by preincubation of the cells with EPO plus 5-HD.Compared with control group,the expression of XIAP of HK-2 cells in asphyxia group were significantly decreased(P0.05),but compared with asphyxia group,the expression of XIAP on HK-2 cells in EPO pretreatment cells were significantly increased(P0.05),joined 5-HD,the effect could be inhibited.Conclusion EPO can relieve the apoptosis of HK-2 cells induced by postasphyxial-serum of neonates." @default.
- W2392880003 created "2016-06-24" @default.
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- W2392880003 date "2009-01-01" @default.
- W2392880003 modified "2023-09-23" @default.
- W2392880003 title "Effect of Erythropoietin on Apoptosis of Human Renal Tubular Cells Induced by Postasphyxial-Serum of Neonates" @default.
- W2392880003 hasPublicationYear "2009" @default.
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