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- W2392885514 abstract "Objective: To study the clinical effects of calcium phosphate cement(CPC)in the repair of bone defects.Methods: Among 94 patients with bone defect,59 patients were male and 35 patients were female,ranging in age from 11 to 72 years,with an average of 39.4 years.All defects were repaired with CPC.The bone defects were located as follows:thoracolumbar vertebrae in 38 patients,calcaneus in 25 patients,tibia in 15 patients,femur in 7 patients,proximal humerus in 3 patients,distal radius in 5 patients and proximal phalanx in 1 patient.The causes of bone defects were fracture in 63 patients,osteomyelitis in 20 patients,bone cyst in 6 patients,fibrous dysplasia in 4 patients and enchondroma in 1 patient.The size of bone defects ranged from 1 cm×1 cm~4 cm×20 cm .The weight of CPC packed into the bone defects ranged 3 to 42 g.Among 74 patients treated with simple CPC repair,38 patients with thoracolumbar fractures underwent vertebroplasty with calcium phosphate artificial bone,25 patients with fractures were fill with CPC at sites of defects after reduction,and 11 patients with benign tumor of bone were filled with CPC at sites of defects after curettage.Twenty patients with osteomyelitics were treated with antibiotic-loaded CPC.Results: All the 94 patients were followed-up,ranged from 14 to 48 months (average,29.6 months).There were no allergic or toxic reaction,no rush or high fever,no fluctuation of serum calcium and phosphate and alkaline phospholatase,no pruritus around the incision in all patients.The X-ray examination showed that the implanted CPC was firmly bonded to the bone at the interface and the anatomic contour of the bone at the sites of defects was successfully restored,and no ablation occurred.Degradation and new-bone formation were found in some patients.Incisions oozing light yellow fluids were found in 9 patients,bacterial culture of the fluids is negative,and then healed through dressing changes.Conclusion: CPC is safe and nontoxic,which is an ideal substitute for autograft in the repair of bone defects.Antibiotic-loaded CPC is an ideal treatment option for osteomyelitis." @default.
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- W2392885514 date "2007-01-01" @default.
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- W2392885514 title "Clinical application of calcium phosphate cement in the repair of bone defects" @default.
- W2392885514 hasPublicationYear "2007" @default.
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