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- W2392886107 abstract "Objective To study the expression and clinical significance of P-gp,GST-π and Topo Ⅱα in gastric and colorectal cancers. Methods The expression of P-gp, GST-π and Topo Ⅱα in 83 cases with gastric or colorectal cancer were examined by immunohistochemistry S-P. Results The positive expression rates of P-gp, GST-π, Topo Ⅱα in normal tissue and gastric and colorectal cancers were 69.9% , 65.1% , 50.6% and 83.1% , 85.5%, 45.8% , respectively. The positive rates of P-gp and GST-Ⅱα in gastric and colorectal cancer were significantly higher than those in normal gastric and colorectal tissue （ P 〈 0.05 ）. The expression of Topo Ⅱα in poorly differentiated cancers was significantly higher than that in well- and moderately differentiated cancers. There was no correlation between other items and clinicapathological parameters （ P 〉 0. 05 ）. Conclusion P-gp, GST-π and Topo Ⅱα play important role in muhidrug resistance. Their mechanisms of drug resistance were different. The detection of expression of P-gp, GST-π and Topo Ⅱα has an important guiding significance in chemotherapy for gastric and colorectal cancers.Key words: Stomach neoplasms ; Colorectal neoplasms ; P-glycoprotein ; Glutathione S-transferase-π ; Topoisomerase Ⅱα" @default.
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- W2392886107 date "2005-12-01" @default.
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- W2392886107 title "[Expression of P-gp, GST-pi and Topo II alpha in gastric and colorectal cancers and their clinical significance]." @default.
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