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- W2392886840 abstract "Objective:To study the pharmacokinetics and bioavailability of rapid dissolving tablet of famotidine in mouth and famotidine market tablet in rabbits.Methods:Rapid dissolving tablets in mouth and market tablets of famotidine were single dose orally given to rabbits.The blood levels of famotidine was determined by HPLC method.Results:The AUC,C max and T max of rapid dissolving tablets in mouth of famotidine were (2 687.63±461.65)(ng·h)/ml,(658.18±84.97)ng/ml and (1.29± 0.23)h,and the AUC,C max and T max of market tablet of famotidine were (1 477.65± 484.28) (ng·h)/ml, (202.80±57.29) ng/ml and (2.85±0.54)h.Conclusion:There is significant difference ( P 0.01) between the AUC of two products,and the bioavailability of rapid dissolving tablet of famotidine in mouth is 181.88%. [" @default.
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- W2392886840 date "2001-01-01" @default.
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- W2392886840 title "The pharmacokinetics and relative bioavailability of rapid dissolving tablet of famotidine in mouth" @default.
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