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- W2392922239 abstract "Objective:To study the possible role of LPS and IL-13 on IL-12 production of mesangial cells in vitro.Methods:The production of IL-12 in mesangial cells was detected with ELISA kit under following different treatments:①Mesangial cells were cultured with LPS(20 μg/ml)under different time;②The cells were cultured with different concentrations of LPS for 24 h.For observation of the effect of IL-13 on IL-12 production by mesangial cells,three groups were designed:control group,LPS(10 μg/ml)group and different concentrations of IL-13 with LPS (10 μg/ml).ELISA was applied to detect IL-12 in supernatants fluid from mesangial cells cultured for 24 h.The expression of IL-12p40 mRNA by mesangial cells cultured for 20 h was evaluated by RT-PCR.Results:Under basal conditions (no LPS) the production of IL-12 was hardly detected.The levels of IL-12 stimulated by LPS was significantly increased in certain doses,but the levels of IL-12 reduced accompanied with the doses and time increasing of LPS stimulantion.IL-13(1-100 ng/ml) inhibited the protein and mRNA expression of IL-12 in a dose-dependent manner(P0.01).Conclusion:The expression of IL-12 in mesangial cells could be upregulated by LPS,but tolerated with lasting and high doses of LPS stimulation.IL-13 could inhibit IL-12 expression induced by LPS in mesangial cells.IL-13 may regulate renal injury and immune responses as an immunosuppression cytokine." @default.
- W2392922239 created "2016-06-24" @default.
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- W2392922239 date "2008-01-01" @default.
- W2392922239 modified "2023-09-23" @default.
- W2392922239 title "The effect of LPS and IL-13 on IL-12 production of mesangial cells in vitro" @default.
- W2392922239 hasPublicationYear "2008" @default.
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