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- W2392935008 abstract "Objective:To evaluate the expression of CD44S and CDV3、CDV6 protein in breast cancer and its clinical significance. Methods:Sixty cases of formalin-fixed paraffin-embedded breast cancer were retrospectively analyzed using S-P immunohistochemical method with the monoclonal antibody CD44S、CD44V3 and CD44V6. The prognostic value of the CD44S、CD44V3 and CD44V6 was assessed using univariate and multivariate survival analysis. Results:Positive rates of CD44S、CD44V3、CD44V6 expression in breast cancer were 78.3%,75.0% and 78.3%. There was significant correlation between CD44s、CD44V6 immunoreactivity and tumor location,lymph node metastasis,and Dukes' stage (P0.05). CD44V3 expression will not be viewed as an independent prognostic indicator. Conclusion:CD44S and CD44V6 might play some important roles in metastasis of breast cancer,and CD44V3 expression might not be an useful independent prognostic marker of breast cancer cell." @default.
- W2392935008 created "2016-06-24" @default.
- W2392935008 creator A5071144254 @default.
- W2392935008 date "2008-01-01" @default.
- W2392935008 modified "2023-09-23" @default.
- W2392935008 title "Expression of CD44_S、CD44_(V3) and CD44_(V6) proteins in breast cancer and its relevance with clinical significance" @default.
- W2392935008 hasPublicationYear "2008" @default.
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