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- W2392944747 abstract "Objective To explore the effect of carbenoxolone on neurons injury after focal cerebral ischemia. Methods A rat model of middle cerebral artery occlusion and reperfusion was made by the intraluminal occlusion technique. 70 SD rats were randomly divided into control group, drug treated group and sham operated group, 10 rats in each. Carbenoxolone, a gap junction blocker, was injected on left side of cerebral ventricle 2 h before operation. Rats in the control group were injected with N.S. in the same route. All the rats were valuated by the behavior scores, brain edema and infarct volume 24 h after the operation. TUNEL staining was used to detect the delayed neuronal death in hippocampus 3 d after ischemia. Results Compared with the control group, the behavior scores, brain edema, infarct volume and rate of delayed neuronal death were significantly decreased (P0.01)in the experimental group. 50% of rats without carbenoxolone developed delayed neuronal death 3 d after operation, while only 20% in carbenoxolone treated rats. The incidence of delayed neuronal death was markedly abated(P0.05). Conclusion Carbenoxolone can protect neurons after focal cerebral ischemia." @default.
- W2392944747 created "2016-06-24" @default.
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- W2392944747 date "2009-01-01" @default.
- W2392944747 modified "2023-09-24" @default.
- W2392944747 title "The Effect of Carbenoxolone on Neurons Injury after Focal Cerebral Ischemia" @default.
- W2392944747 hasPublicationYear "2009" @default.
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