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- W2392972339 abstract "Objective To observe the effects of Rhizoma Paridis total saponins(RPTS) on the growth of human gastric carcinoma cell lines MNK-45 and MGC80-3.Methods MNK-45 and MGC80-3 cells were treated with 5,10,20,40,and 80 μg/ml RPTS for 24,48,and 72 h,and then methyl thiazolyl tetrazolium(MTT) assay was used to measure the growth inhibition rates of the two cells.MNK-45 and MGC80-3 cells were treated with 10 μg/ml RPTS for 24 h,and then acridine orange/ethidium(AO/EB) staining was used to observe the morphological changes of the two cells.MNK-45 and MGC80-3 cells were treated with 10 and 20 μg/ml RPTS,and then flow cytometry was used to determine the changes in cell cycles of the two cells.Results RPTS(5-80 μg/ml) had significant inhibitory effects on the growth of MNK-45 and MGC80-3 cells(P0.05 or P0.01),and the higher the dosage was,the longer and stronger the inhibitory effect was(P0.01).RPTS had significantly stronger inhibitory effects on MNN-45 cells than on MGC80-3 cells when applied at the same concentration for the same period(P 0.01).Both cells showed apoptotic features under a fluorescence microscope after being treated with RPTS.Treated with RPTS,MNK-45 cells were arrested in G0/G1 phase,and MGC80-3 cells in S phase.Conclusion RPTS can inhibit cell growth,induce apoptosis,and affect cell cycle in human gastric carcinoma cell lines MNK-45 and MGC80-3,but the effects on cell growth and cell cycle were different in them." @default.
- W2392972339 created "2016-06-24" @default.
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- W2392972339 date "2012-01-01" @default.
- W2392972339 modified "2023-09-23" @default.
- W2392972339 title "Effects of Rhizoma Paridis Total Saponins on Growth of Gastric Carcinoma Cell Lines MNK-45 and MGC80-3" @default.
- W2392972339 hasPublicationYear "2012" @default.
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