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- W2392974429 abstract "Dronedarone hydrochloride(1),a potent blocker of multiple ion,was approved for atrial fibrillation by Food and Drug Administration(FDA) in 2009.It's a modified synthetic analogue of amiodarone,which decreases lipophilicity and results in a shorter lifetime and lower tissue accumulation.Here a new process for compound 1 was achieved with 33% overall yield starting from commercial p-aminophenol(2).N-(4-oxocyclohexa-2,5-dien-1-yl)-methanesulfonamide(4) which was obtained by mesylation and oxidization from compound 2 reacted with methyl 3-oxoheptanoate followed by cyclization to afford N-[2-butyl-3-methoxycarbonyl-5-benzofuranyl]-methanesulfonamide(6).The inversion of compound 6 into the desired compound 1 was realized by hydrolyzation and chlorination followed by Friedel-Crafts reaction with N-butyl-N-(3-phenoxypropyl)-1-butanamine hydrochloride.This process is characterized by cheap and readily available mate-rials,shorter procedures,mild reaction conditions and convenient work-up,making it practical in industry." @default.
- W2392974429 created "2016-06-24" @default.
- W2392974429 creator A5077856035 @default.
- W2392974429 date "2013-01-01" @default.
- W2392974429 modified "2023-09-25" @default.
- W2392974429 title "New Process for Preparation of Dronedarone Hydrochloride" @default.
- W2392974429 hasPublicationYear "2013" @default.
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