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- W2392974957 abstract "Objective To observe positive rate anti neutrophil cytoplastic antibody(ANCA),its indirect immunofluoresence(IIF) modes and target antigens distribution in many kinds of primary and secondary glomerulo diseases,in the same time,explore its clinic importance.Methods The normal controls(n=150) came from the healthy blood donors.The cases (n=252) were all kinds of glomerular disease patients,among them,182 did renal biopsy.All subjects serum was assayed of ANCA with the method of IIF, the positive (1∶20 titer) then was assayed proteinase 3 of(PR3),medullar peroxidase(MPO),lactoferritin(LF) ELISA extensively.The statistic analysis χ 2 test was used.Results The controls′ positive rate was obviously lower than the cases (0% vs 4.8 %,P 0.05 ).There were totally 12 positive in the cases,expectively C ANCA,atypical ANCA and P ANCA (1,1,10),and the target antigens are MPO,LF and others,PR3 was not visual.ANCA's positive rate varied with the disease type from 0% to 4.5 %.It was more often seen in secondary glomerular diseases than in the primary,especially in the lupus nephritis(LN) (17%).In the view of pathology,it was usually seen in IgA nephropathy,Henoch Sch ¨o nlein purpura nephritis(HSPN) and Ⅵ LN.Conclusion ANCA's positive rate is approximately 5% in all kinds of glomerular diseases,and varible with the disease types.It is the most highest in the LN.P ANCA,atypical ANCA are often seen,but rarely C ANCA,the antigen specificity are often MPO,LF and others?but rarely PR3.Using ANCA,LN can be distinguished from HSPN,HBV GN and others,moreover,proper treatment and predict in on prognosis of associated diseases can be available." @default.
- W2392974957 created "2016-06-24" @default.
- W2392974957 creator A5086470272 @default.
- W2392974957 date "2003-01-01" @default.
- W2392974957 modified "2023-09-23" @default.
- W2392974957 title "Test and importance of anti-neutrophil cytoplasmic antibody in glomerular diseases" @default.
- W2392974957 hasPublicationYear "2003" @default.
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