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- W2392985807 abstract "Objective To investigate the inhibitory effects of cromoglicate sodium on the mast cells in rats with lung arterial hypertrophy,and to investigate the correlation between the function of mast cells and pulmonary vascular remodeling. Methods The constriction operation on the openings above coronary aorta( supracoronary aortic banding) was performed on male adult SD rats to establish the PH- LHD rat models. Cromoglicate sodium was given to the treatment group,while replaced saline was given to the rats in model group and sham operation group. Pulmonary vascular remodeling,and mast cell aggregation and degranulation were observed,while peripheral MCP- 1 and IL- 6 were assessed using ELISA. Results Mast cell accumulation around pulmonary arterioles was observed on the 36 thday,which was alleviated by cromoglicate sodium treatment. The peripheral MCP- 1 and IL- 6 were significantly elevated in model group when comparing with those in the other 2 groups,which was significantly reduced by cromoglicate sodium treatment( P 0. 05). Conclusion Mast cell accumulation and degranulation around pulmonary arterioles with diameter between 20 and50 μm plays important role in the pathogenesis of pulmonary hypertension. Membrane stabilizer,cromoglicate sodium,can reduce the inflammatory factors,including MCP- 1 and IL- 6,thus to inhibit the function of mast cells." @default.
- W2392985807 created "2016-06-24" @default.
- W2392985807 creator A5057647448 @default.
- W2392985807 date "2015-01-01" @default.
- W2392985807 modified "2023-09-26" @default.
- W2392985807 title "The inhibitory effect of cromoglicate sodium on mast cells in rats with lung arterial hypertrophy" @default.
- W2392985807 hasPublicationYear "2015" @default.
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