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- W2392987404 abstract "Objective: To investigate the relativity of tumor necrosis factorα (TNFα), monocyte chemotasis protein 1(MCP1) and the activity of nuclear factorκB(NFκB) in the intestinal tissue in sepsis rats, and the mechanism of rhubarb on sepsis. Methods: The sepsis model of rat was established by cecum ligation and puncture. The rats were killed at 1, 3, 6, 12, 24 and 48 hours after operation and the intestinal mucosa tissue was sampled. The contents of TNFα and MCP1 were detected by enzyme linked immunoadsorbent assay, and the activity of NFκB was detected by electrophoresis mobility shift assay. Sepsis rats were treated with rhubarb, then were killed after 12, 24, 48 and 72 hours, the contents of TNFα and MCP1 as well as the activity of NFκB were detected by the same methods as above. Results : Compared to the control group, the activity of NFκB, the contents of TNFα and MCP1 of intestinal mucosa were increased in sepsis rats(all P 0 01). Rhubarb possessed the effect of inhibiting the increase of TNFα , MCP1 levels and NFκB activity(all P 0 05). Conclusion: TNFα and MCP1 are the cytokines activated in the early stage of sepsis, and the release of them is closely relative to the activation of NFκB . Rhubarb ossesses the action of inhibiting inflammatory reaction by inhibiting NFκB activation and reduce the release of inflammatory cytokines." @default.
- W2392987404 created "2016-06-24" @default.
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- W2392987404 date "2004-01-01" @default.
- W2392987404 modified "2023-09-26" @default.
- W2392987404 title "Inhibitory effects of rhubarb on nuclear factor-κB activation in rats with sepsis" @default.
- W2392987404 hasPublicationYear "2004" @default.
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