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- W2392987508 abstract "Objective To investigate the variation of brain evoked potentials(BEPs) and their clinical applications in patients with Alzheimer's disease(AD). Methods Four kinds of BEPs (auditory brainstem response, ABR; auditory evoked potentials, AEP; flash visual evoked potentials, F VEP; event related potentials, ERPs P300) were recorded from 39 patients diagnosed as AD according to DSM III R and 40 age matched normal controls(NC), using a Dantec Concerto SEEG 16 instrument. Results The AD patients presented lower amplitudes(ABR V, AEP P2,F VEP P2, P300 P2 P3),prolonged latencies( ABR III, AEP P1, N1 P2 ) and shortened latencies ( N1 of both target and nontarget P300), as compared to NC group. All the above mentioned BEP indexes except N1 latency of target P300 were found significantly correlated with one cognitive assessment (CASI score), and some of them were also significantly correlated with the years of education(ED) received by the subjects. K Means cluster analysis revealed that, the indexes correlated with both CASI and ED, could differentiate the subject groups with a better specificity (100 0%); and the ones correlated only with CASI could do so with a better sensitivity (93 6%). Conclusions The variation of BEP in AD is essentially parallel with the degree of impaired cognition. Some BEP indexes might be developed into the tool for cognitive assessment, and of their potentials the clinical application were suggested." @default.
- W2392987508 created "2016-06-24" @default.
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- W2392987508 date "1999-01-01" @default.
- W2392987508 modified "2023-09-24" @default.
- W2392987508 title "A preliminary study of brain evoked potentials in patients with Alzheimer's disease" @default.
- W2392987508 hasPublicationYear "1999" @default.
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