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- W2392992103 abstract "Objective:To observe the effect of VitD3 and/or TGF β1 on acute promonocytic leukemia cell line U937.Methods:The cell cycle,proliferation and differentiation were studied by typanblue dye exclusion,light microscope,immunocytochemistry (ICC),flow cytometry(FCM)and image analyser.The expressions of TGF β1 mRNA and TGF β1 were studied by in situ hybridization(ISH)and enzyme linked immunosorbent assays(ELISA).Results:VitD3 combined with TGF β1 could obviously inhibit the proliferation of U937 cells and interfer the growth in G0/G1 phase.These effects were significant than those using VitD3 or TGF β1 alone ( P 0.05).VitD3 combined with TGF β1 could develop the expression of CD14 and down regulate expression of C-myc mRNA.They were also significant than those using VitD3 or TGF β1 alone by image analysis ( P 0.01).The expressions of TGF β1 mRNA and TGF β1 of U937 cell were developed with the development of the dose of VitD3(25,250,2 500 ng·ml 1 ).Conclusion:VitD3 could inhibit the proliferation and induce the differentiation of U937 cells.VitD3 combined with TGF β1 had significant effects of inhibition on U937 cell and interfer U937 cell in G0/G1 phase.Definite dose of VitD3 could induce U937 cells to autocrine TGF β1 and down regulate expression of C myc mRNA." @default.
- W2392992103 created "2016-06-24" @default.
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- W2392992103 date "2000-01-01" @default.
- W2392992103 modified "2023-09-25" @default.
- W2392992103 title "Study on the effect of 1α,25-(OH)_2 Dihydroxyvitamin and TGF-β1 on leukemic cells line U937" @default.
- W2392992103 hasPublicationYear "2000" @default.
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