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- W2392992457 abstract "Objective:To investigate the lesion of hypertrophic myocardial cell membrane in the molecular level.Method:The model of rat abdominal aortic constraction was adopted,the distribution of anionic sites at the basal lamina of hypertrophic myocardial cells in the rats was observed with a cationic probe,polyethylenimine(PEI),Ca+{2+} level in myocardial cell and activity of Ca+{2+}|ATPase of myocardial sarcolemma were measured Result:It was observed that the anionic sites of basal lamina of the myocardial cells in control rats were orderly arranged in linear manner at the distarce of 40～80 nm.The number of PEI particles were reduced significantly in operated rats,there was a dissociation between basal lamina and plasma membrane,the loss of lamina integrity and the rupture of the plasma membrane in operated rats was observed. Ca+{2+} level in myocardial cell and activity of Ca+{2+}|ATPase of myocardial sarcolemma were markedly decreased.Conclusion:These results indicate that there is a decrement of the anionic sites of basal lamina and there is a membrane protective barrier dysfunction in hypertrophic myocardial cells." @default.
- W2392992457 created "2016-06-24" @default.
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- W2392992457 date "2002-01-01" @default.
- W2392992457 modified "2023-09-24" @default.
- W2392992457 title "Changes of anionic sites on hypertrophic myocardial cell membrane" @default.
- W2392992457 hasPublicationYear "2002" @default.
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