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- W2392995006 abstract "The extracts of Y-1、Y-P、Y-A、Y-E、Y-A-1 and Y-3-11 from Melastoma normale were tested for ability to inhibit the activies of HIV reverse transcriptase and human deoxyribonucleic acid(DNA) polymerase.Among 15 fractions,Y-1、Y-A、Y-A-1、Y-9 and Y-11 showed very strong inhibition enzyme activities.The 50% inhibition concentrations(IC50) 0.1～0.5μg/ml for HIV reversetranscriptase and 0.5～2.5μg/ml for DNA polymerase α.HIV reverse transcriptase was inhibited by 99.37%,93.35%,98.24%,99.92%and 89.68% in the presence of Y-A、Y-A-1(2.5μg/ml),Y-9、Y-11(2 μg/ml)and Y-1(5 μg/ml) respectively.DNA polymerase αwas inhibited by 95.45%,93. 33%, 93.01% and 99.11% in the presence of Y-A、Y-9、Y-11(2.5 μg/ml)and Y-1(5μg/ml)respectively.These results indicated that the M.normale contained as vet unidentified substance which inhibited the activities of HIV reverse transcriptase and cellular DNA polymerases." @default.
- W2392995006 created "2016-06-24" @default.
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- W2392995006 date "1995-01-01" @default.
- W2392995006 modified "2023-09-25" @default.
- W2392995006 title "Differential Inhibitory Effects and Separation of Melastoma normale Extracts on the Activities of HIV Reverse Transcriptase and DNA Polymerase" @default.
- W2392995006 hasPublicationYear "1995" @default.
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