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- W2393014750 abstract "Objective To evaluate the clinical significance of HPV L1 capsid protein detection in the diagnosis of cervical intraepithelial neoplasia(CIN)and its predictive value to disease outcome,and explore more reasonable and effective diagnosis of treatment of CIN.Methods Cervical biopsy were performed on 187 HPV-DNA(+)women who received the testing of TCT,HPV L1 capsid protein in Drum Tower Hospital affiliated to Nanjing University.The result of histopathologic test was recognized as gold standard,and a follow-up study was done to 114 women who received treatment or review in this hospital.Results (1)Cervical biopsy in different pathological group CIN1,CIN2,CIN3,L1 positive rates were 49.12%,30.00%,20.45% by chi-square test,χ2=10.437,P=0.015,there was a statistically significant difference.The positive rate of L1 in CIN1 group than the other groups,and several other groups showed no difference between the positive rate of L1,CIN2 and CIN3 combined with CIN1 group was the chi-square test,χ2=9.443,P=0.002,there was a statistically significant difference.(2)During 2 years of follow-up results without operation in group L1(+)and L1(-)HC2 negative rates,there was significant difference,P=0.022.(3)HPV L1 capsid protein on CIN1 outcome prediction function,CIN1 in L1 patients with positive HPV negative rate was L1 negative high.Conclusions (1)The positive rate of L1 in CIN1 group was higher than the other groups,and several other groups showed no difference between the positive rate of LI.(2)Results of 2 years of follow-up without operation in group L1(+)and L1(-)HC2 negative rates,there was significant difference.(3)HPV L1 capsid protein can be used as CIN1 clinical prognostic indices." @default.
- W2393014750 created "2016-06-24" @default.
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- W2393014750 date "2013-01-01" @default.
- W2393014750 modified "2023-09-27" @default.
- W2393014750 title "Clinical value of HPV L1 capsid protein in diagnosis of cervical intraepithelial neoplasia and forecast of its outcome" @default.
- W2393014750 hasPublicationYear "2013" @default.
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