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- W2393014987 abstract "The animal model was established by adding different doses of Mo into drinking water as the control group(Mo:0 mg/L),the Mo 100 group(Mo:100 mg/L),the Mo 200 group(Mo:200 mg/L) and the Mo 400 group(Mo:400 mg/L).On the 120th day of the treatment,the blood and hepar tissue were collected with the activities of SOD and GSH-Px and the content of MDA in serum determined by spectrophotometer.The histopathological and ultrastructural changes of the liver were observed by light microscope and transmission electron microscope(TEM).The Smac and Bax protein expressions were determined by the method of immunohistochemistry.In result,the activities of SOD and GSH-Px were significantly decreased,and the MDA content in serum was significantly increased in the Mo 200 group and the Mo 400 group,respectively.High Mo induced the hepatocytes swelling degeneration,liver sinusoidal endothelial cells hyperplasia,the structure of liver cells fuzzy,atrophy even necrosis.Under the TEM,swollen mitochondria and expanded endoplasmic reticulum were observed in the Mo 200 group and Mo 400 group.The level of Smac and Bax protein expressions were significantly increased in the Mo 200 group and the Mo 400 group.The result showed that Mo induced lipid peroxidation and the changes were dose-dependent.In addition,high doses of Mo significantly increased expressions of the apoptosis-related protein Smac and Bax." @default.
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- W2393014987 date "2012-01-01" @default.
- W2393014987 modified "2023-09-28" @default.
- W2393014987 title "Effect of molybdenum on lipid peroxidation and expression of Smac and Bax in mice" @default.
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