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- W2393015864 abstract "Objective To explore whether proinsulin (PI) and true insulin (TI) are related to cardiovascular risk factors. Methods PI and TI levels of 119 subjects during 2 h 75 g OGTT after an overnight 14 h fast were detected by BA ELISA in which proinsulin crossreactivity is less than 0.1%. The relationship between PI, TI levels and traditional cardiovascular risk factors was assessed by spearman correlation, partial corrclation and multiple regression analysis. Results Fasting and 2h PI, TI were positively related to the number of traditional cardiovascular risk factors ( r =0 19-0 33), BMI ( r =0 23-0 41) and WHR ( r =0 32-0 51), negatively related to HDL C ( r =-0 22- -0 30). Fasting PI and 2h PI, TI were positively associated with IGT ( r =0 13-0 34), hypertension ( r =0 18-0 20), UA ( r =0 27-0 36) and TG ( r =0 32-0 33), fasting and 2h PI were positively related to apolipoprotein B ( r =0 26), 2h PI was also positively related to TC ( r =0 22); but after adjusting for age, sex, BMI, WHR, fasting and 2h blood glucose, the relationship between TI and blood lipids disappeared, the relationship between PI and blood lipids weakened or disappeared. In multiple regression analyses, PI level was more strongly associated with triglycerides, total cholesterol and apolipoprotein B than TI level. Conclusion PI and TI, whether fasting or post glucose loading, are closely related to cardiovascular risk factors." @default.
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- W2393015864 date "2001-01-01" @default.
- W2393015864 modified "2023-09-27" @default.
- W2393015864 title "Relationship of proinsulin and true insulin to cardiovascular risk factors in non-diabetic subjects" @default.
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