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- W2393022684 abstract "Aim To investigate the effects of J2 on murine splenocytes. Methods 24 BALB/c were divided into 3 groups randomly and were treated with intraperitoneal injection of placebo,CsA and J2,respectively. The drugs were delivered for 12 days consecutively. Murine splenocytes were stimulated by ConA and anti-CD3mAb. IL-2,IFN-γ,IL-4 and IL-10 of cyto-supernatant were measured by ELISA.The index of cell proliferation and production of cytokine was compared.Results After stimulation by ConA, the average index of cell proliferation in the control group was (9.61±2.20). Treatment with J2 led to a statistically significant decrease of index of cell proliferation (6.53±3.21,P0. 01) and production of IL-2 and IFN-γ. But compared with treatment with CsA there was no statistically significant difference between the two groups (P0.05).After stimulation by anti-CD3mAb, the average index of cell proliferation in the control group was (9.52±2.44).There was no statistically significant difference between the groups. Conclusion These results showed that J2 could inhibit proliferation of T cells and decrease the production of cytokine by Th1." @default.
- W2393022684 created "2016-06-24" @default.
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- W2393022684 date "2007-01-01" @default.
- W2393022684 modified "2023-09-25" @default.
- W2393022684 title "Effect of Micromolecular Compound J2 on Murine Splenocytes" @default.
- W2393022684 hasPublicationYear "2007" @default.
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