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- W2393022811 abstract "Objective:To investigate the expressions of toll-like receptor 4 (TLR4) on circulating monocytes,TNF-α and hsCRP in patients with acute coronary syndrome(ACS),and to explore the relationships between TLR4 and coronary arteriosclerosis disease(CAD). Method:Expressions of TLR4 on circulating monocytes from 32 controls,12 patients with stable angina (SA),24 patients with unstable angina (UA),24 patients with acute myocardial infarction (AMI) were compared with the use of flow-cytometry. The concentration of tumor necrosis factor-alpha(TNF-α)and high-sensitivity C-reactive protein (hsCRP) were analyzed by radio immunoassay (RIA) and immune turbidimetry method.The difference of the expressions of TLR4,TNF-α and hsCRP,as well as the correlation between TLR4 and TNF-α or hsCRP,were analysed.Result:Expressions of TLR4 were significantly increased above controls and patients with UA and AMI group (P0.05). This was paralleled by enhanced levels of TNF-α (AMI [17.23±6.62],UA[16.22±5.03],versus SA[10.26±2.83],controls [10.15±2.30];P0.05) and hsCRP (AMI [10.86±11.08],UA [4.69±3.80] versus SA [0.82±0.32],controls[ 0.67±0.27];P0.05). Conclusion:ACS is associated with increased expressions and signding events downstream of TLR4 which suggests TLR4 activation as signaling mechanism in immune-mediated progression of CAD." @default.
- W2393022811 created "2016-06-24" @default.
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- W2393022811 date "2009-01-01" @default.
- W2393022811 modified "2023-09-28" @default.
- W2393022811 title "Enhanced expressions of toll-like receptor 4 on circulating monocytes in patients with acute coronary syndrome" @default.
- W2393022811 hasPublicationYear "2009" @default.
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