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- W2393024307 abstract "Objective To investigate of the protective mechanism in erythropoietin(EPO)on hypoxic-ischemic brain damage of neonatal rats.Methods Fifty-four Wistar rats at the age of 7-day-old were divided into three groups,including normal group,HIBD groups,and EPO treatment group.After the model of HIBD was established,rats were killed at 24 h,48 h,and 72 h respectively.Then the activity of superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in brain tissues were detected correspondingly.Results Lower SOD activity and higher MDA content were showed in HIBD groups when compared with normal group from rats.Moreover,there were significantly higher SOD activity and lower MDA content appeared in EPO treatment on normal group than those in HIBD groups.Conclusion Erythropoietin can reduce the level of oxygen free radicals caused form injury by regulating the activity of SOD,which may be one of protective mechanisms on hypoxic-ischemic brain damage." @default.
- W2393024307 created "2016-06-24" @default.
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- W2393024307 date "2012-01-01" @default.
- W2393024307 modified "2023-09-23" @default.
- W2393024307 title "Protective mechanism of erythropoietin on hypoxic-ischemic brain damage" @default.
- W2393024307 hasPublicationYear "2012" @default.
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