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- W2393025382 abstract "OBJECTIVETo investigate the anticancer function of adenosine triphosphate magnesium chloride(ATP-MgCl 2) on lung adenocarcinoma cells.METHODSHuman lung adenocarcinoma cell (A549) was divided into four groups. Each group was added with corresponding drug every day to the newly changed culture medium. After four days culture, the inhibiting rate of cancer cells was measured by cell counting and the change of exterior and interior cellular structure was observed by electron microscope.RESULTSThe growth of cancer cells was inhibited markedly in ATP-MgCl 2 group and ATP group, lots of cells were ultimately killed. ATP-MgCl 2 showed higher growth inhibition rate and cytotoxic activity than ATP in the first two days. In MgCl 2 group, the growth of cancer cells was unaffected. With electron microscope, it was observed that in ATP group the microvilli of cancer cells were shortened and reduced remarkably, the nucleoli became annular. In the group of ATP-MgCl 2, the microvilli of cancer cells were shortened significantly and the number reduced significantly or even disappeared, and the surface of cells became velvet, and nucleoli became annular too. CONCLUSIONATP-MgCl 2 not only induces differentiation, but also shows a marked inhibitory and cytotoxic activity on human adenocarcinoma cell line (A549), because MgCl 2 can form an active compound with ATP, which increases the anticancer function of ATP." @default.
- W2393025382 created "2016-06-24" @default.
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- W2393025382 date "2002-01-01" @default.
- W2393025382 modified "2023-09-27" @default.
- W2393025382 title "Anticancer function of adenosine triphosphate magnesium chloride on lung adenocarcinoma cells" @default.
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