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- W2393026369 abstract "AIM: To observe the ultrastructure of intraosseous vascular endothelial damage and thrombosis in a glucocorticoid and LPS induced osteonecrosis in rabbits. METHODS: Sixteen New Zealand white rabbits were divided into osteonecrosis model group (n=10) and control group (n=6). In model group, LPS (30 μg/kg) was given intravenously twice at an interval of 24 h, and then, 24 h after the second injection of LPS, dexamethasone (7.5 mg/kg) was given 5 times to the animals at an interval of 24 h. Saline infusion (0.5 ml/kg) was given in the control group. After pressurized perfusion with heparin-saline and 10% formalin to hind limbs, the femoral head specimens were retrieved at week 8 postoperatively. Decalcified sections were prepared from half of the femoral heads, stained with hematoxylin and eosin, examined histologically for osteonecrosis. Undecalcified sections were prepared from the other half of the specimens, and then they were cleared of embedding material and were dried at critical-point and coated with gold-palladium in a high-vacuum evaporator. The sections were examined under scanning electron microscope for observing ultrastructural changes of the surface of microvascular endothelium in subchondral bone. RESULTS: The scanning electron microscope revealed irregular lumen, rough surface of microvascular endothelium or tamponade,or thrombosis of the subchondral vessels in model group, which were consistent with the features of histological examination. CONCLUSION: Endothelium damage and thrombosis of the subchondral vessels were the important features in the development of microcirculatory disturbance in glucocorticoid and LPS induced osteonecrosis." @default.
- W2393026369 created "2016-06-24" @default.
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- W2393026369 date "2006-01-01" @default.
- W2393026369 modified "2023-09-23" @default.
- W2393026369 title "Ultrastructural examination for microcirculatory disturbance in glucocorticoid and LPS induced osteonecrosis" @default.
- W2393026369 hasPublicationYear "2006" @default.
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