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- W2393026537 abstract "Objective: To evaluate effects of different doses of allergen on ovalbumin (OVA)-induced acute and sub-acute mouse models of asthma by intranasal challenge. Methods: In brief, intranasal inhalation challenge with different doses of OVA (25, 50 and 100μg, respectively) was performed to induce acute and sub-acute mouse models of asthma. The respiratory function parameters of excited group and control group were measured using an invasive pulmonary function device. After collecting bronchoalveolar lavage fluid (BALF) of each group the cells were counted. Histological staining with HE, Congo red, Masson and Periodic acid-Schiff (PAS) were employed in paraffin-embedded sections derived from the left lungs to identify inflammatory cell infiltration, collagen deposition, mucus expression and other indicators. Results: Compared with 25 μg OVA- challenged group and saline group, at day of 20, 24, 100 and 50μg OVA-challenged groups showed the bronchial hyperresponsiveness and the elevated numbers of inflammatory cells including eosinophils in BAL fluid, the alveolar and bronchial wall, as well as in bronchial lumen and blood vessels. Bronchial mucosal folds were increased, extended and thickened, with a large amount of mucous sputum plugs in the bronchial lumens and significant deposition of collagen fibers in the bronchial and blood vessels. Additionally, PAS staining showed increased mucus in bronchial lumen. Conclusion: With different doses of intranasal inhalation of OVA, we successfully established varying degrees of acute and sub-acute mouse models of asthma. Our studies provided the foundation for further research on the pathogenesis and drug screening of asthma using mouse models." @default.
- W2393026537 created "2016-06-24" @default.
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- W2393026537 date "2012-01-01" @default.
- W2393026537 modified "2023-09-23" @default.
- W2393026537 title "Effects of different doses of allergen on acute and subacute mouse models of asthma" @default.
- W2393026537 hasPublicationYear "2012" @default.
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