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- W2393029316 abstract "Objective To study the relationship between expression of p27 KIP1 and progression of hepatocellular carcinoma(HCC).Methods The expression of p27 KIP1 in 52 cases of HCC was detected by immunohistochemistry of strept avidin biotin complex and mRNA in situ hybridization.Results The positive cells of p27 KIP1 protein were diffused in HCC.The positive signal was localized in nuclei.The labeling index (LI) of p27 KIP1 protein was significantly higher in tumor surrounding tissues than that in tumor tissues. p27 KIP1 protein LI showed a positive correlation with the differentiation grade of HCC.The better differentiation of cancer cells, the higher LI of p27 KIP1 protein ( P 0.01).The positive cells of p27 KIP1 mRNA were also diffused in HCC.The positive signal was localized in nuclei and cytoplasm. As to the expression of p27 KIP1 at the mRNA level,there was no significant correlation with tumor surrounding tissues and stages of HCC.Conclusionp27 KIP1 protein is associated with progression and differentiation grade of hepatocellular carcinoma." @default.
- W2393029316 created "2016-06-24" @default.
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- W2393029316 date "2003-01-01" @default.
- W2393029316 modified "2023-09-23" @default.
- W2393029316 title "Study on p27~(KIP1) Expression in Hepatocellular Carcinoma" @default.
- W2393029316 hasPublicationYear "2003" @default.
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