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- W2393030844 abstract "Objective: To investigate the acute and chronic effects of cholesterol on the contraction of extracorporeal gallbladder muscle strips of guinea pigs and their mechanism.Methods: The effects of cholesterol on the contraction of in vitro gallbladder muscle strip(group A) and gallbladder strip incubated in cholesterol for two hours(group B) were recorded by tonotransducer and compared.Results: Cholesterol could inhibit the contraction of extracorporeal gallbladder muscle strip partly.Compared with that in group A,the response to CCK-8 changed significantly in group B(P0.05).The response of CCK-8 on the contraction of in vitro gallbladder muscle strip could be inhibited partly by cholesterol(changed by 69.2%,P0.05).The effects of cholesterol on the contraction of extracorporeal gallbladder muscle strip were inhibited partly by atropine and nimodipine(changed by 64.2% snf 62.1% respectively,both P0.05).Although cholesterol was administered,no significant difference in the contrating amplitude of smooth muscle strip was found in group B(P0.05).Conclusion: After gallbladder muscle strips incubation in cholesterol for two hours,the tension and its sensitivity to CCK-8 would decrease;cholesterol can inhibit the contraction of extracorporeal gallbladder muscle strip partly,and its inhibitory effect is mediated by the cholinergic receptor,CCK receptor and Ca2+.Cholesterol may influence the contraction of gallbladder strip through interstitial cells of Cajal." @default.
- W2393030844 created "2016-06-24" @default.
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- W2393030844 date "2009-01-01" @default.
- W2393030844 modified "2023-09-26" @default.
- W2393030844 title "Acute and Chronic Effects of Cholesterol on the Contraction of Extracorporeal Gallbladder Muscle Strips of Guinea Pigs" @default.
- W2393030844 hasPublicationYear "2009" @default.
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