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- W2393036167 abstract "The activities and mKNA expression of UDP-glucuronosyltransferase (UDP-GT) in hepatocytes were investigated in 18 patients with primary intrahepatic stone and 7 controls. Methods:①With UDP-glucuronic acid and 2-aminophenol as the substrate, UDP-GT activities were analyzed. The glucose 6-phosphatase, taken as a reference, was also measured.②By using in situ hybridization, the expression of UDP-GT mRNA was determined with digoxigenin-la-belecl UDP-GT cDNA probe. Results: Abnormal low activity of hepatic UDP-GT was found in 27% of 28 patients with primary intrahepatic stone, as compared with only 14% in 7controls. The UDP-GT mRNA expression was lower in the patients' hepatic tissues. But there was no significant statistic difference between the patient group and the controls. Con-elusion:Hepatoyte UDP-GT activity is discreased in patients with intrahepatic stone." @default.
- W2393036167 created "2016-06-24" @default.
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- W2393036167 date "1998-01-01" @default.
- W2393036167 modified "2023-09-28" @default.
- W2393036167 title "In situ hybridization of UDP-GT mRNA in hepato-cytes from patients with primary intrahepatic stone" @default.
- W2393036167 hasPublicationYear "1998" @default.
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