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- W2393036479 abstract "Objective:To establish implant model of diabetic rats and compare the effects of tonifying kidney recipes (TKR) and aminoguanidine on the osseointegration of titanium implants, and to provide effective methods to improve the osseointegration of the diabetics. Methods: HE staining were used to observe the bone histomorphometric parameters. Results: Three days after streptozocin injection, increase of blood sugar(P0.05) showed in pathologic group, with urine sugar positive. Light microscope observation: Twelve weeks after implantation, combined bone lamella relatively thick, continuity fairly good, surface smooth, many osteoblasts around, with fairly high density of osteocytes in TKR group. In the aminoguanidine group, the combined bone lamella relatively thin but continuity fairly good, also many osteoblasts seen around, and the density of osteocytes relatively high. Histomorphometric parameters comparison (12 weeks after the implantation): Combined bone lamella width, the numbers of the implant area osteoblasts and osteocytes and the non-implant area osteocytes in diabetic group are smaller than those in TKR and aminoguanidine groups (P0.05); the bone lamella width, the numbers of the implant area osteoblasts and osteocytes in aminoguanidine group significantly smaller than those in TKR(P0.05). Conclusion: Aminoguanidine can improve the osseointegration of titanium implants by controlling diabetes, while TKR can improve the osseointegration of titanium implants by controlling diabetes and modulating bone metabolism more effectively." @default.
- W2393036479 created "2016-06-24" @default.
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- W2393036479 date "2009-01-01" @default.
- W2393036479 modified "2023-09-24" @default.
- W2393036479 title "Effects of tonifying kidney recipes and Aminoguanidine on the osseointegration of titanium implants in diabetic rats——an experimental study" @default.
- W2393036479 hasPublicationYear "2009" @default.
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