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• W2393038729 abstract "Objective To observe the anti-schistosomiasis egg granuloma and hepatic fibrosis effects in C57BL/6 mice immunized with UV-attenuated cercariae(UVC) vaccine.Methods Sixty C57BL/6 mice were divided into two groups,a UVC group and infection control group.The mice of the UVC group were challenged with cercariae of Schistosoma japonicum five weeks after immunizing with UVC.The mice in the infection control group were challenged with the same number of cercariae.The mice were sacrificed 7 weeks after the challenge infection to get the left livers.The consecutive paraffin sections of the livers were made and stained with haematoxylin and eosin,and the size of single egg granulomas was measured with micrometer.The levels of hyaluronic acid(HA) and laminin(LN) in sera of the mice were determined by ELISA.The expression of TGF-β1mRNA of the livers were examined by PCR-ELISA.Results The mean hepatic egg granuloma diameters of the two experimental groups,the UVC group and infection control group,were(176.25±38.67) μm and(304.38±53.23) μm,respectively.The hepatic granulomas were significantly smaller in the UVC group than those in the infection control group.The liver granuloma size of mice in the UVC group was decreased by 42.10% in diameter as compared with the infection control group.The levels of HA and LN in sera of mice of the UVC group were significantly lower than those of the infection control group(P0.01).The amount of TGF-β1mRNA isolated from the livers of mice in the UVC group decreased significantly.Conclusions UVC vaccine acts as an effective inhibitor against egg granulomas of Schistosoma japonicum and reduces immunopathological damage caused by Schistosoma japonicum in the host." @default.
• W2393038729 created "2016-06-24" @default.
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• W2393038729 date "2009-01-01" @default.
• W2393038729 modified "2023-09-23" @default.
• W2393038729 title "Anti-schistosomiasis effect induced by UV-attenuated cercariae of Schistosoma japonicum in C57BL/6 mice" @default.
• W2393038729 hasPublicationYear "2009" @default.
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