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- W2393040876 abstract "Objective: To compare the changes of secretory immunoglobulin(SIgA) in gastrointestinal mucosa in hepatocirrhosis rats before and after liver transplantation.Methods: Hepatocirrhosis model was established in rats by subcutaneous injection of 40% carbon tetrachloride and rat liver transplantation model was made with two-cuff technique.The changes of SIgA in stomach,duodenum,upside of small intestine and ileum-appendices were detected with radioimmunoassay and mononuclear cell cytotoxicity assay before and after liver transplantation.At the same time,the effects of operation stress on SIgA were compared.Results: Operation itself could affect the level of SIgA in gastrointestinal mucosa,but it recovered shortly after operation.Before liver transplantation,the levels of SIgA in stomach,duodenum,upside of small intestine and ileum-appendices in hepatocirrhosis rats were lower than those in normal rats.After liver transplantation,the level of SIgA in gastrointestinal mucosa increased gradually and even appeared similar to the normal level,especially in duodenum.Conclusion: Hepatocirrhosis can restrain the secretion of SIgA in gastrointestinal mucosa.After the liver transplantation,the level of SIgA in gastrointestinal tissues increases gradually,which indicates the recovery of gastrointestinal immune function." @default.
- W2393040876 created "2016-06-24" @default.
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- W2393040876 date "2006-01-01" @default.
- W2393040876 modified "2023-09-22" @default.
- W2393040876 title "Effects of liver transplantation on secretion of SIgA at gastrointestinal mucosa in hepatocirrhosis rats" @default.
- W2393040876 hasPublicationYear "2006" @default.
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