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- W2393045899 abstract "Objective To observe the long-term toxicity of doxepin hydrochloride cream on local skin of rabbits for 30d.Methods 40 rabbits were randomly divided into 4 groups.Each group was administrated on their local skin with doxepin hydrochloride cream at dose of 0,25,50,100 mg/kg·d for up to 30 days,respectively. The change of appearance and behaviour of rabbits should be observed every day during experiment term. The blood was taken from auricular artery of rabbit respectively later 30 days and 14 days after drug stopping. The blood analysis and blood biochemical examination were proceeded. Then bodies of animals were dissected and examined. Their organs was weighted, then the organ coefficient was calculated and pathological examination was proceeded.Results There was no any abnormal change in volume of eaten forage,behavior,body weight, blood examination, blood biochemical examination, organ coefficient and organ pathology compared with control group(i.e, at dose of 0mg/kg·d).Conclusion The safety dose of doxepin hydrochloride cream for rabbits is 100 mg/kg·d,there by which provides the experimental basis in working out the safety dose for human." @default.
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- W2393045899 date "2005-01-01" @default.
- W2393045899 modified "2023-09-27" @default.
- W2393045899 title "Long-term toxicity of Doxepin Hydrochloride Cream in rabbits" @default.
- W2393045899 hasPublicationYear "2005" @default.
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