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- W2393047919 abstract "Objective:To investigate the changes of sugar chain structures of urinary amylase in children leukemia with different traditional Chinese medicine syndrome types,and its relation to free radical.Methods:Lectins-binding ratios of urine amylase,urinary amylase activity,ONOO-,MDA were determined in children leukemia with spleen-deficiency and lever qi stagnation,children non-leukemia patients.Results:Urine amylase activity was elevated in children leukemia,as compared to children non-leukemia patients.In children leukemia,PNA、ConA、PSA-binding ratios of urine amylase were elevated,in children leukemia with spleen-deficiency,PNA,ConA,PSA,LCA-binding ratios of urine amylase were elevated,no significant variation in children leukemia with lever qi stagnation,as compared to children non-leukemia patients.Urine ONOO-,MDA of children leukemia were lower than that of children non-leukemia patients,however,urine ONOO-,MDA of children leukemia with spleen-deficiency were higher than that of children leukemia with lever qi stagnation.A negative correlation was found between WGA、LCA、ConA、PSA-binding ratios and MDA.Conclusion:In children leukemia,urine amylase core-fucosylated,high-mannose-type,hybrid-type sugar chains increased,terminal sialic acid and fucose on the sugar chain decrease,this exist in only children leukemia with spleen-deficiency,not exist in children leukemia with lever qi stagnation,this may be caused by increasing free radical damage amylase sugar chains,maybe spleen-deficiency syndrome type play an important part in generating aberrant amylase sugar chains." @default.
- W2393047919 created "2016-06-24" @default.
- W2393047919 creator A5077682911 @default.
- W2393047919 date "2008-01-01" @default.
- W2393047919 modified "2023-09-23" @default.
- W2393047919 title "The aberrant sugar chains of urinary amylase in children leukemia,of different TCM type" @default.
- W2393047919 hasPublicationYear "2008" @default.
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