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- W2393049023 abstract "Objective:To investigate the effects of G-CSF on gliacyte plasticity and cognitive handicap, and analyze their correlation after subacute cerebral hypoperfusion in aged rats. Methods: 30 male-SD-fourteen-month rats were randomly divided into 2VO/NS group, Sham/NS group and 2VO/G-CSF group, each group has 10 rats. Learning and memory function was accessed by Morris water maze test, the number and cytoplasmic process length of GFAP positive cell in hippocampal CA1 region were analyzed by immunohistochemistry and image analysis. Results: Escape latency of 2VO/NS group was longer than Sham/NS (P 0.01) and 2VO/G-CSF (P0.05). 2VO/NS group spent less time in the platform quadrant than Sham/NS (P0.01) and 2VO/G-CSF (P0.05). As for time of crossing the platform area, 2VO/NS group was less than Sham/NS and 2VO/G-CSF (P0.01). The number of GFAP positive cell in hippocampal CA1 region of 2VO/NS group was significant less than Sham/NS and 2VO/G-CSF (P0.05). The cytoplasmic process length of GFAP positive cell of 2VO/NS group was significant shorter than Sham/NS and 2VO/G-CSF (P0.05). For 2VO/NS, Sham/NS and 2VO/GSF group, the number and cytoplasmic process length of glia cells in hippocampal CA1 region were positive related to spatial memory.Conclusion:After subacute cerebral hypoperfusion, the function of spatial learning and memory were impaired in aged rats, GCSF can enhance congnitive function, promote alteration of gliacyte plasticity. Simultaneously, the alteration of gliacyte plasticity related to improvement of spatial memory." @default.
- W2393049023 created "2016-06-24" @default.
- W2393049023 creator A5008117563 @default.
- W2393049023 date "2010-01-01" @default.
- W2393049023 modified "2023-09-28" @default.
- W2393049023 title "Effects of G-CSF on Cognitive Handicap and Gliacyte Plasticity after Subacute Cerebral Hypoperfusion in Aged Rats" @default.
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