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- W2393050147 abstract "Objective: To investigate the population pharmacokinetics(PPK) of the orally administered theophylline sustained-release tablets and the effect of gatifloxacin on theophylline PPK in the elderly patients with chronic obstructive pulmonary disease(COPD),so as to obtain scientific support for the adjustment of the regimen schedule and individualized dosage.Methods: A Non-linear Mixed Effects Modeling(NONMEM) program was applied to the analysis of the population data of theophylline sustained-release tablets,based on the 256 steady-state serum concentrations of theophylline from 16 elderly COPD patients after oral administration of theophylline sustained-release tablets alone and then concurrently with gatifloxacin.The one-compartment open model with first-order absorption was employed as the basic pharmacokinetics model.Inter-individual variability of parameters ka,CL/F,V and ALAG were estimated with the exponential model,while intra-individual variability(residual error) with the addition model.Quantitative analyses were made of the effect of covariate,such as concurrent use of gatifloxacin(GAT=1,otherwise GAT=0),body weight(BW),age and biochemical indicators,on theophylline pharmacokinetic parameters.Results: The standard values of ka,CL/F,V and ALAG were 1.38 h-1,1.33 L/h,46.4 L and 0.486 h,respectively.The final regression equations for typical population parameters CL/F and V were as follows: C■/F = 1.33 ×(1-0.138×GAT),■=46.4×(BW/57)1.44.The mean absolute weighted residual of theophylline serum concentration between individual predicted and observed values was(5.60±4.55)%.Conclusion: The clearance rate of theophylline sustained-release tablets decreases 13.8% when used concurrently with gatifloxacin.The best function adjustment for parameter V is the average to the power of 1.44 in proportion to body weight.These characteristics are useful for regulating the dose schedule." @default.
- W2393050147 created "2016-06-24" @default.
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- W2393050147 date "2008-01-01" @default.
- W2393050147 modified "2023-09-23" @default.
- W2393050147 title "Effects of gatifloxacin on population pharmacokinetics of theophylline in elderly patients with chronic obstructive pulmonary disease" @default.
- W2393050147 hasPublicationYear "2008" @default.
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