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- W2393053948 abstract "Objective To investigate multiparametric immunophenotypic features in patients with acute myelocytic leukemia(AML)-M_2 bearing AML-1/ETO gene rearrangements and its predicting value.Methods A multiparametric flow cytometry was used in the study of phenotypic characterization of the subtype of AML.Immunophenotype of 30 patients with AML(M_2/ETO~+)was analyzed by fluorescence in situ hybridization(FISH).The results were compared with 36 patients of AML-M_2 with AML-1/ETO~- (M_2/ETO~-)and 34 acute promyelocytic leukemia(APL)patients.Results There were a population. 15.89%-68.53% the blast cell and a population of more differentiated and heterogeneous myeloid cells in the marrow of 30 patients with M_2/ETO~+.The blast cells had a myeloid phenotype(CD_(33),CD_(13)and MPO) and showed a characteristic pattern of antigen expression.The fluorescent intensity of CD_(33)in patients with M_2/ETO~+ was less than in patients with M_2/ETO~-and APL [ mean fluorescent intensity(MFI):98±75 v. 244±184 and 845±523,both P0.01 ].The patients with M_2/ETO~+ showed higher expression of CD_(19) (27/30,90.0%)and coexpression of CD_(34)~+ CD_(56)~+(27/27,100%)compared with M_2/ETO~-(4/36, 11.11%;9/36,25.0%)and APL(3/34,8.82%;0/34,0%),and a lower positive rate of CD_9~+ MPO~+ (0/14,0%)and higher positive of HLA-DR(30/30,100%)than APL(30/32,93.75% and 9/33, 27.27%).The granulocytic differentiation antigen CD_(15)/CD_(11b)was present in the patients of M_2/ETO~+.It could be divided into CD_(15)~+CD_(11b)~-and CD_(15)~+ CD_(11b)~+.The granulocytes significantly expressed CD_(56)(22/27, 81.48%)in patients with M_2/ETO~+ compared to patients with M_2/ETO~-(8/36,22.22%)and patients with APL(6/34,17.56%).Conclusion The AML-M_2 patients with AML-1/ETO gene rearrangements displays an exclusive immunophenotype which is highly predictive of the gene rearrangement and can be use to differentiate M_2/ETO~+ from APL." @default.
- W2393053948 created "2016-06-24" @default.
- W2393053948 creator A5077552203 @default.
- W2393053948 date "2007-01-01" @default.
- W2393053948 modified "2023-09-23" @default.
- W2393053948 title "Multiparametric immunophenotypic features of acute myelocytic leukemia-M_2 patients with AML-1/ETO fusion gene" @default.
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