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- W2393055204 abstract "Objective To investigate the serum IL-18 levels in HIV carriers/AIDS patients and their relations with viral load and the expression of coreceptors CCR5/CXCR4 on CD+4T lymphocytes.Methods Serum IL-18 levels of 42 HIV carriers/AIDS patients and 12 healthy controls were determined by ELISA,and their relations with serum viral load were analyzed.Flow-cytometry was used to detect the coreceptors CCR5/CXCR4 expressions on CD+4T lymphocytes in whole blood samples from 42 HIV carriers/AIDS patients.The correlation of the coreceptors expression with serum IL-18 levels and viral load was analyzed.Results Forty two HIV carriers/AIDS patients had significantly raised IL-18 levels compared with healthy controls(P0.01),and there was significantly higher serum IL-18 levels in AIDS group C than AIDS in AIDS group A according to 1993 CDC standard(USA)(P0.01).A significantly positive correlation among serum IL-18 levels,viral load and the CXCR4 expression on CD+4T lymphocytes was identified(P0.05).Conclusions The persistently raised serum IL-18 levels in HIV carriers/AIDS patients will possibly exacerbate their immunodeficiency status,and may also be involved in the pathogenesis of the disorder itself." @default.
- W2393055204 created "2016-06-24" @default.
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- W2393055204 date "2007-01-01" @default.
- W2393055204 modified "2023-09-23" @default.
- W2393055204 title "Correlation between the expression of CCR5/CXCR4 and raised serum levels of interleukin-18 in HIV carriers/AIDS patients" @default.
- W2393055204 hasPublicationYear "2007" @default.
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