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- W2393055303 abstract "Objective: To study the proliferative effects of homocysteine on vascular smooth muscle cells. Methods: Rat aortic smooth muscle cells cultured in vitro, were treated with different concentrations of homocysteine for 72 h. The cultured cells were measured by MTT colorimetric assay and flow cytometric method (FCM). Twenty SD rats were randomized into control diet group (Group C) and high methionine group (Group M). The serum amino acids were examined after 12 w. Meanwhile the pathological assay of aorta was examined. Results: 1.Homocysteine had promotive effect on the proliferation of aortic smooth muscle cells; 2.Homocysteine accelerated aortic smooth muscle cells from G 1-phase to S-phase; 3.After 12 w, the rat of group M had hypermethioninemia and hyperhomocysteinemia; 4.The thickness of artery media and the number of smooth-muscle cells were increased; 5.The cell exhibited dilatation of endoplasmic reticulum and deformation of mitochondriae. Conclusion: Homocysteine promoted proliferation of the smooth muscle cells." @default.
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- W2393055303 date "2002-01-01" @default.
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- W2393055303 title "Effect of homocysteine on the growth of smooth muscle cells" @default.
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