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- W2393055526 abstract "To investigate the efficacy of hgp100, a human melanoma associate antigen, in inducing specific anti-murine melanoma immune response and in protection via hgplOO plasmid. Methods Plas-mids pcDNA3-hgp100 and pcDNA3-mgp100 were constructed by using full-length hgp100 and mgp100 coding sequence inserted into pcDNA3 vectors respectively. C57BL/6 mice were immunized intramuscularly with pcDNA3, pcDNA3-mgp100 and pcDNA3-hgp100 three times at two week intervals, separately. Specific anti-tumor antibody derived from immunized serum was detected kinetically by ELISA. Specific proliferation and cytotoxicity against B16F10 were detected. IFN-γand IL-4 cytokines were measured. Mice immunized with plasmids were finally challenged with B16F10 melanoma tumor to observe the functional protection. Results Mice immunized with pcDNA3-hgp100 exhibited a significant protection (survival as long as 68 days) as compared to the mice immunized with pcDNA3-mgp100 only (survival to 29 days). Both T cell proliferation and cytotoxicity against murine melanoma were enhanced by hgp100 DNA immunization. An increased IFN-γrelease and antibody production could also be detected after immunization with the pcDNA3-hgp100. Conclusion The data strongly indicated that anti-tumor immune response and protection against murine melanoma could be induced by human gp100, implicating a potential approach in anti-tumor immunotherapy." @default.
- W2393055526 created "2016-06-24" @default.
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- W2393055526 date "2006-01-01" @default.
- W2393055526 modified "2023-09-25" @default.
- W2393055526 title "Human gp100 induces specific anti-murine melanoma immune response, implicating a potential way to antitumor immunotherapy" @default.
- W2393055526 hasPublicationYear "2006" @default.
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